| Date | Time | Opponent | Location | Score |
|---|---|---|---|---|
| 03/07/10 | 1:00 PM | @ Houston Dynamo | Carl Lewis Track Stadium | T 1-1 |
| 03/14/10 | 5:00 PM | Houston Dynamo | Nelson Field | L 0-1 |
| 03/26/10 | 7:30 PM | @ Laredo Heat | Laredo, Texas | W 2-1 |
| 03/31/10 | 12:00 PM | @ FC Dallas | Dallas, Texas | L 1-4 |
| 04/11/10 | 6:00 PM | Montreal Impact | House Park | W 2-0 |
| 04/17/10 | 7:10 PM | @ AC St. Louis | St. Louis Soccer Park | W 2-1 |
| 04/25/10 | 6:00 PM | Rochester Rhinos | House Park | L 1-2 |
| 04/28/10 | 7:30 PM | Haiti Men's National Team | House Park | T 0-0 |
| 05/01/10 | 7:00 PM | @ NSC Minnesota Stars | NSC Stadium | W 2-1 |
| 05/08/10 | 6:30 PM | @ Tampa Bay Rowdies | George M. Steinbrenner Field | T 2-2 |
| 05/16/10 | 6:00 PM | Crystal Palace Baltimore | House Park | W 2-1 |
| 05/19/10 | 7:30 PM | Tampa Bay Rowdies | House Park | T 3-3 |
| 05/26/10 | 6:30 PM | @ Miami FC Blues | Lockhart Stadium | W 3-1 |
| 05/29/10 | 6:00 PM | @ Crystal Palace Baltimore | UMBC Stadium | W 2-0 |
| 06/05/10 | 7:30 PM | Puerto Rico Islanders | House Park | W 2-1 |
| 06/09/10 | 7:30 PM | Portland Timbers | House Park | T 0-0 |
| 06/12/10 | 7:30 PM | Vancouver Whitecaps | House Park | L 1-2 |
| 06/15/10 | 7:30 PM | DFW Tornados | House Park | W 3-0 |
| 06/19/10 | 7:30 PM | Miami FC Blues | House Park | W 3-1 |
| 06/22/10 | 7:30 PM | Arizona Sahuaros | House Park | W 3-1 |
| 06/26/10 | 6:30 PM | @ Miami FC Blues | Lockhart Stadium | W 2-1 |
| 06/29/10 | 9:30 PM | @ Chivas USA | Fullerton, Calif. | L 0-1 |
| 07/03/10 | 7:30 PM | Puerto Rico Islanders | House Park | T 1-1 |
| 07/09/10 | 6:30 PM | @ Rochester Rhinos | Marina Auto Stadium | T 0-0 |
| 07/17/10 | 7:30 PM | AC St. Louis | House Park | W 2-0 |
| 07/31/10 | 7:30 PM | Miami FC Blues | House Park | W 3-1 |
| 08/07/10 | 7:30 PM | Tampa Bay Rowdies | House Park | W 4-2 |
| 08/14/10 | 7:05 PM | @ Puerto Rico Islanders | Estadio Juan Ramón Loubriel | L 0-2 |
| 08/22/10 | 6:00 PM | Carolina Railhawks | House Park | W 3-2 |
| 08/26/10 | 9:00 PM | @ Portland Timbers | PGE Park | T 1-1 |
| 08/29/10 | 6:00 PM | @ Vancouver Whitecaps | Swangard Stadium | T 2-2 |
| 09/04/10 | 7:30 PM | NSC Minnesota Stars | House Park | W 2-0 |
| 09/11/10 | 7:05 PM | @ Puerto Rico Islanders | Estadio Juan Ramón Loubriel | |
| 09/16/10 | 6:30 PM | @ Tampa Bay Rowdies | George M. Steinbrenner Field | |
| 09/18/10 | 7:10 PM | @ AC St. Louis | St. Louis Soccer Park | |
| 09/25/10 | 7:30 PM | AC St. Louis | House Park | |
| 10/01/10 | 6:00 PM | @ Carolina Railhawks | WakeMed Soccer Park | |
| 10/03/10 | 1:00 PM | @ Montreal Impact | Saputo Stadium |